|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
MTHFR gene C677T rather than A1298C polymorphism may be associated with PC.
|
31701291 |
2020 |
|
rs397507444
|
|
|
0.050 |
GeneticVariation |
BEFREE |
MTHFR gene C677T rather than A1298C polymorphism may be associated with PC.
|
31701291 |
2020 |
|
rs13181
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The present meta-analysis showed significant associations between deoxyribonucleic acid (DNA) repair gene (X-ray repair cross-complementing group 1 (XRCC1) Arg399GIn and Arg194Trp, excision repair cross complementation 1 (ERCC1) rs11615 and rs3212986, ERCC2 rs13181) polymorphisms and PC risk.
|
31393355 |
2019 |
|
rs13181
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In addition, haplotype analysis revealed that haplotype AGG, which comprised rs13181, rs3916874 and rs238415, was associated with a 1.401-fold increase in pancreatic cancer risk (p < 0.05).
|
29260835 |
2019 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The present meta-analysis showed significant associations between deoxyribonucleic acid (DNA) repair gene (X-ray repair cross-complementing group 1 (XRCC1) Arg399GIn and Arg194Trp, excision repair cross complementation 1 (ERCC1) rs11615 and rs3212986, ERCC2 rs13181) polymorphisms and PC risk.
|
31393355 |
2019 |
|
rs121913529
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Importantly, FGTI-2734 inhibited the growth of xenografts derived from four patients with pancreatic cancer with mutant KRAS (2 G12D and 2 G12V) tumors.
|
31227505 |
2019 |
|
rs121913529
|
|
|
0.050 |
GeneticVariation |
BEFREE |
KRAS G12D point mutation plays an important role in the incidence of non-small-cell lung cancer (NSCLC) as well as colorectal cancer, pancreatic cancer and breast cancer.
|
30876538 |
2019 |
|
rs3212986
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The present meta-analysis showed significant associations between deoxyribonucleic acid (DNA) repair gene (X-ray repair cross-complementing group 1 (XRCC1) Arg399GIn and Arg194Trp, excision repair cross complementation 1 (ERCC1) rs11615 and rs3212986, ERCC2 rs13181) polymorphisms and PC risk.
|
31393355 |
2019 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Importantly, FGTI-2734 inhibited the growth of xenografts derived from four patients with pancreatic cancer with mutant KRAS (2 G12D and 2 G12V) tumors.
|
31227505 |
2019 |
|
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Results from our stratified analysis based on Hardy-Weinberg equilibrium (HWE) showed that there was a robust significant association between Arg280His polymorphism and pancreatic cancer risk (allelic model, OR 0.743, 95% CI 0.576-0.958, P = 0.022; heterozygous model, OR 0.701, 95% CI 0.525-0.936, P = 0.016; dominant model, OR 0.710, 95% CI 0.537-0.939, P = 0.016).
|
29285737 |
2019 |
|
rs11655237
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<b>Background:</b> Two genome-wide association studies (GWASs) identified LINC00673 rs11655237 was associated with susceptibility to pancreatic cancer.
|
31118802 |
2019 |
|
rs11655237
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Long noncoding RNA LINC00673 has been widely explored for its role in the development and prognosis of many tumors, and 2 genome-wide association studies identified that LINC00673 rs11655237 was associated with susceptibility to pancreatic cancer.
|
30286619 |
2019 |
|
rs104894230
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Importantly, FGTI-2734 inhibited the growth of xenografts derived from four patients with pancreatic cancer with mutant KRAS (2 G12D and 2 G12V) tumors.
|
31227505 |
2019 |
|
rs1131691021
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Importantly, FGTI-2734 inhibited the growth of xenografts derived from four patients with pancreatic cancer with mutant KRAS (2 G12D and 2 G12V) tumors.
|
31227505 |
2019 |
|
rs11615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present meta-analysis showed significant associations between deoxyribonucleic acid (DNA) repair gene (X-ray repair cross-complementing group 1 (XRCC1) Arg399GIn and Arg194Trp, excision repair cross complementation 1 (ERCC1) rs11615 and rs3212986, ERCC2 rs13181) polymorphisms and PC risk.
|
31393355 |
2019 |
|
rs1370041903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed that, in one patient with pancreatic cancer, the expression of a truncated form of SPOP (p.Q360*) lacking the nuclear localization signal led to nuclear accumulation of NANOG, which promoted growth and metastasis of pancreatic cancer cells.
|
31624231 |
2019 |
|
rs1537373
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our study provided evidence that rs1537373 in ANRIL may influence transcription factor binding and regulate CDKN2B expression, thus confer the susceptibility to PC.
|
30604909 |
2019 |
|
rs1561927
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of our study was to investigate the contribution of two lncRNAs polymorphisms (rs1561927 and rs4759313 of PVT1 and HOTAIR, respectively) in PC susceptibility.
|
30475759 |
2019 |
|
rs1630747
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that three novel SNP (ie, rs3124761, rs17458086 and rs1630747) were significantly associated with PanC risk (P = 5.17 × 10<sup>-7</sup> , 5.61 × 10<sup>-4</sup> and 5.52 × 10<sup>-4</sup> , respectively).
|
30972876 |
2019 |
|
rs17458086
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that three novel SNP (ie, rs3124761, rs17458086 and rs1630747) were significantly associated with PanC risk (P = 5.17 × 10<sup>-7</sup> , 5.61 × 10<sup>-4</sup> and 5.52 × 10<sup>-4</sup> , respectively).
|
30972876 |
2019 |
|
rs2001389
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele G of rs2001389 weakened the binding activity with CTCF, and it was related to the lower expression of a putative antioncogene MFSD13A whose knockdown promoted proliferation of PC cells.
|
31237042 |
2019 |
|
rs200349340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our studies revealed that functional SNP rs4759314 and rs200349340 of HOTAIR had strong associations with PC susceptibility.
|
30867650 |
2019 |
|
rs2162679
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant relationship was found between rs2195239 and breast or pancreatic cancer risk. rs2162679 reduces the overall cancer risk in allele, homozygote, dominant, and recessive models, as well as reducing cancer risk in Asian populations in allele, homozygote, and recessive models.
|
30654740 |
2019 |
|
rs2195239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant relationship was found between rs2195239 and breast or pancreatic cancer risk. rs2162679 reduces the overall cancer risk in allele, homozygote, dominant, and recessive models, as well as reducing cancer risk in Asian populations in allele, homozygote, and recessive models.
|
30654740 |
2019 |
|
rs2736100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we present a novel genome-wide candidate SNP for PDAC risk (TERT-rs2736100), a completely new signal (NAF1-rs7675998) approaching genome-wide significance and we report a strong association between the teloscore and risk of pancreatic cancer, suggesting that telomeres are a potential risk factor for pancreatic cancer.
|
30325019 |
2019 |